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KMID : 0370220170610030158
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Yakhak Hoeji
2017 Volume.61 No. 3 p.158 ~ p.163
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Wheat Sprout Extract Stimulates Cell Proliferation via Phosphorylation of ERK and Akt in Human Dermal Papilla Cells
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Park Seol-A
In Myung-Hee
Woo Won-Hong
Mun Yeun-Ja
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Abstract
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We investigated the effect of Wheat Sprout MeOH extract (WSM) on cell proliferation, and analyzed the molecular mechanism in human hair dermal papilla cells (HHDPCs). After exposure to WSM in HHDPCs, cell proliferation was increased compared with minoxidil-treated cells. Treatment with WSM led to phosphorylation of extracellular signal-related kinase (ERK) and Akt. Moreover, WSM-mediated increase of cell proliferation was attenuated by PD98059, ERK inhibitor, and LY294002, Akt inhibitor. These results suggest that WSM induced cell proliferation in HHDPCs through activation of ERK and Akt.
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KEYWORD
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Wheat Sprout, HHDPCs, Cell Proliferation, ERK, Akt
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